the effect of central injection of ghrelin and bombesin on mean plasma thyroid hormones concentration

نویسندگان

fariba mahmoudi physiology faculty, payame noor university, east azarbaijan , malekan center, iran.

fatemeh mohsennezhad physiology faculty, payame noor university, azarbijan shargi, malekan center, iran

homayoun khazali physiology faculty, shahid beheshti university, tehran, iran.

haleh ehtesham biology faculty, payame noor university, iran.

چکیده

ghrelin increases food intakes and body weight. bombesin decreases food intakes and inhibits the stimulatory effect of ghrelin on food intakes. thyroid hormones have a crucial role in the regulation of body weight and yet the effect of bombesin on thyroid axis activity is not fully clear. therefore, the goal of this study was to determine the effect of different doses of ghrelin or bombesin on mean plasma thyroid-stimulating hormone (tsh), triiodothyronine (t3) and thyroxin (t4) concentration and also, the effect of interaction between ghrelin and bombesin on thyroid axis activity. forty-nine rats in seven groups received saline or different doses of ghrelin (4, 10 or 15 nmol) and bombesin ( 2.5, 5 or 10 nmol) and forty-two rats in six groups received simultaneous injection of ghrelin (10 or 15 nmol) and different doses of bombesin (2.5, 5 or 10 nmol) via lateral cerebral ventricle. blood samples were collected via decapitation 20 min after the injection and plasma was assayed for plasma tsh, t3 and t4 concentration by radioimmunoassay (ria). ghrelin significantly decreased the concentration of mean plasma thyroid hormones compared to saline. bombesin did not significantly increase thyroid hormones concentration compared to saline but bombesin blocked the inhibitory effect of ghrelin on thyroid axis activity. bombesin may be the antagonist of ghrelin action.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Effect of Central Injection of Ghrelin and Bombesin on Mean Plasma Thyroid Hormones Concentration

Ghrelin increases food intakes and body weight. Bombesin decreases food intakes and inhibits the stimulatory effect of Ghrelin on food intakes. Thyroid hormones have a crucial role in the regulation of body weight and yet the effect of bombesin on thyroid axis activity is not fully clear. Therefore, the goal of this study was to determine the effect of different doses of Ghrelin or bombesin on ...

متن کامل

The Effect of Central Injection of Ghrelin and Bombesin on Mean Plasma Thyroid Hormones Concentration

Ghrelin increases food intakes and body weight. Bombesin decreases food intakes and inhibits the stimulatory effect of Ghrelin on food intakes. Thyroid hormones have a crucial role in the regulation of body weight and yet the effect of bombesin on thyroid axis activity is not fully clear. Therefore, the goal of this study was to determine the effect of different doses of Ghrelin or bombesin on ...

متن کامل

The Effect of Central Injection of Ghrelin and Bombesin on Mean Plasma Thyroid Hormones Concentration

Ghrelin increases food intakes and body weight. Bombesin decreases food intakes and inhibits the stimulatory effect of Ghrelin on food intakes. Thyroid hormones have a crucial role in the regulation of body weight and yet the effect of bombesin on thyroid axis activity is not fully clear. Therefore, the goal of this study was to determine the effect of different doses of Ghrelin or bombesin on ...

متن کامل

The effects of interactions between testosterone and ghrelin on mean plasma thyroid hormones concentration in male rats

Ghrelin is an orexigenic peptide synthesized mainly by stomach and hypothalamus. Ghrelin decreases secretion of thyroid hormones. Testosterone is an esteroidogenic hormone that exerts stimulatory effects on Hypothalamus-Pituitary-Thyroid (HPT) axis activity. The aim of the present study was to investigate the effect of interactions between the central injection of ghrelin and testosterone on me...

متن کامل

the effect of ghrelin and estradiol on mean concentration of thyroid hormones

results the results indicated that ghrelin significantly decreased thyroid hormone concentrations, whereas estradiol increased these concentrations. the simultaneous injection of ghrelin and estradiol significantly decreased the inhibitory effect of ghrelin on thyroid hormone concentrations (p < 0.05). conclusions according to the results of this study, both ghrelin and estradiol affect the con...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of pharmaceutical research

جلد ۲۰۱۱، شماره ۹، صفحات ۶۲۷-۶۳۲

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023